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Methsolon 1G IV/IM Injection
Methsolon Injection (Methylprednisolone Sodium Succinate)-Potent Anti-Inflammatory Corticosteroid for Acute & Chronic Conditions
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✅ Description:
🔹 Endocrine Disorders
Primary or secondary adrenocortical insufficiency
- Acute adrenal crisis
- Congenital adrenal hyperplasia
- Nonsuppurative thyroiditis
- Cancer-associated hypercalcemia
- Shock unresponsive to standard treatment
🔹 Rheumatic Diseases
- Rheumatoid arthritis, including juvenile forms
- Psoriatic arthritis, gouty arthritis
- Ankylosing spondylitis
- Bursitis, epicondylitis, tenosynovitis
🔹 Collagen Vascular Diseases
- Active flares of systemic lupus erythematosus (SLE)
- Polymyositis, dermatomyositis
- Acute rheumatic carditis
🔹 Skin Conditions
- Severe psoriasis, seborrheic dermatitis, pemphigus
- Exfoliative dermatitis, Stevens-Johnson syndrome
- Bullous dermatitis herpetiformis, mycosis fungoides
🔹 Allergic Reactions
- Bronchial asthma, contact dermatitis, atopic dermatitis
- Drug-induced allergic reactions
- Acute allergic laryngeal edema
- Anaphylactic reactions (supportive therapy)
🔹 Ophthalmic Inflammatory Disorders
- Iritis, chorioretinitis, keratitis
- Optic neuritis, uveitis, allergic conjunctivitis
- Herpes zoster ophthalmicus, corneal ulcers
🔹 Gastrointestinal Conditions
- Ulcerative colitis and Crohn’s disease during severe flares
🔹 Respiratory Diseases
- Sarcoidosis, aspiration pneumonitis
- Pulmonary tuberculosis (in combination with anti-TB therapy)
- Berylliosis, Loeffler’s syndrome
🔹 Hematologic Disorders
- Autoimmune and idiopathic thrombocytopenic purpura
- Hemolytic anemia, erythroblastopenia
- Secondary thrombocytopenia
🔹 Oncology Support
- Adjunct in leukemias and lymphomas in adults
- Acute lymphoblastic leukemia in children
🔹 Edematous States
- Treatment of idiopathic nephrotic syndrome (non-uremic)
- Lupus nephritis with significant proteinuria
🔹 Neurological & Infectious Conditions
- Tuberculous meningitis (with subarachnoid block)
- Trichinosis with neurological or myocardial involvement
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🧪 Slow tapering is essential after prolonged use to avoid adrenal suppression.
✔️ How Methsolon Works – Pharmacology
Methsolon contains methylprednisolone, a synthetic glucocorticoid similar to the body’s natural hormones. It exerts:
Strong anti-inflammatory, anti-allergic, and immunosuppressive effects
Rapid onset of action when given via IV or IM injection
Long-lasting relief from inflammation by suppressing immune cell activity and cytokine release
Higher potency than prednisolone (5:4 ratio) with less water/salt retention
✔️ When Methsolon Injection is Prescribed
Methsolon Injection is a fast-acting corticosteroid medication indicated for the treatment of a wide range of medical conditions due to its powerful anti-inflammatory and immunosuppressive properties. Its therapeutic applications include:
✔️ Dosage & Administration Guidelines
- Routes: IV push, IV infusion, or IM injection
- High-dose therapy: 30 mg/kg IV over 30 minutes, repeated every 4–6 hours for up to 48 hours in life-threatening conditions
- Standard dose: 10–40 mg IV/IM, adjusted based on condition severity
- Pediatric dosing: 0.11–1.6 mg/kg/day in divided doses, minimum of 0.5 mg/kg/day
- Multiple sclerosis flare: 160 mg IV daily for 3 days
✔️ 🧪 Reconstitution Instructions
Add 8 mL (500 mg) or 16 mL (1 gm) of sterile Water for Injection
Shake well until fully dissolved
Administer immediately; discard any unused portion
✔️ 🚫 Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or excipients
- Idiopathic thrombocytopenic purpura (IM route)
- Intrathecal administration is strictly prohibited
✔️ Warnings, Precautions & Use in Special Populations
- Monitor for hypertension, glucose intolerance, osteoporosis, peptic ulcer, and infection
- Use the lowest effective dose and taper slowly
- Avoid live vaccines during therapy
- In pediatric patients, long-term use may affect growth velocity
- Caution in the elderly due to a higher risk of systemic effects
✔️ Drug Interactions
⚠️ May interact with NSAIDs, antidiabetics, warfarin, cyclosporine, estrogens, and ketoconazole
Monitor potassium levels when used with diuretics or amphotericin B
May reduce vaccine effectiveness and interfere with skin test results
✔️ Pregnancy & Lactation
Pregnancy: Use only if the benefits outweigh the risks; potential for fetal adrenal suppression
Lactation: Appears in breast milk; may affect growth and adrenal function in infants—breastfeeding not recommended during treatment
✔️ Storage Guidelines
- Store at 20°–25°C, protected from light
- Use within 48 hours of reconstitution
- Do not autoclave vial
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
